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  • Side reactions in the pyroglutamic acid-7-amino-4-methylcoumarin synthesis.

Side reactions in the pyroglutamic acid-7-amino-4-methylcoumarin synthesis.

International journal of peptide and protein research (1996-07-01)
D Zicane, M Petrova, Z Tetere, G Kreishman, E Brooks, J Karlson, U Kalejs
PMID8844263
ABSTRACT

N-Formylpyroglutamic acid-7-amido-4-methylcoumarine and pyroglutamyl-pyroglutamic acid-7-amido-4-methylcoumarin are the major products in the synthesis of pyroglutamic acid-7-amido-4-methylcoumarin by phosphorus pentachloride in dimethylformamide and dicyclohexylcarbodiimide under pyridine activation.