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  • Compounded preparations with nystatin for oral and oromucosal administration.

Compounded preparations with nystatin for oral and oromucosal administration.

Acta poloniae pharmaceutica (2013-08-08)
Zbynek Sklenár, Vladimír Scigel, Katerina Horácková, Ondrej Slanar
ABSTRACT

Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers may profit from extemporaneous compounding. An appropriate drug therapy for candidiasis (trush) is nystatin, which is a substance available in the Czech Republic for the magistral preparation relatively recently, since 2010. Making formulas for extemporaneous compounding is quite simple and preparations particularly useful for dentists, pediatricians, otolaryngologists, oncologists and gastroenterologists. The authors formulated composition of viscous oromucosal suspension, oral/oromucosal hydrogel and oromucosal gelatine globule which may be present as compounded products containing nystatin for oromucosal and/or oral administration. The preparation is practically verified and magistral products have been already used in clinical practice.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(Hydroxypropyl)methyl cellulose
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, average Mn ~90,000
Sigma-Aldrich
Gelatin from porcine skin, Type A, lyophilized powder, γ-irradiated, BioXtra, suitable for cell culture
Sigma-Aldrich
Methyl cellulose, 26.0-33.0% (methoxyl group, on Dry Basis), meets USP testing specifications, viscosity: 400 cP
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
Sigma-Aldrich
Gelatin from porcine skin, powder, gel strength ~300 g Bloom, Type A, BioReagent, suitable for electrophoresis, suitable for cell culture
Sigma-Aldrich
Methyl cellulose, 27.5-31.5% (Methoxyl content), viscosity: 400 cP
Sigma-Aldrich
Methyl cellulose, viscosity: 15 cP
Sigma-Aldrich
Xylitol
Sigma-Aldrich
Glycerol, ReagentPlus®, ≥99.0% (GC)
Supelco
Glycerin, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Gelatin solution, Type B, 2% in H2O, tissue culture grade, BioReagent, suitable for cell culture
Sigma-Aldrich
Gelatin from porcine skin, gel strength ~175 g Bloom, Type A
Sigma-Aldrich
Gelatin from porcine skin, gel strength 300, Type A
Sigma-Aldrich
Nystatin, powder, BioReagent, suitable for cell culture
Sigma-Aldrich
Glycerin, meets USP testing specifications
Sigma-Aldrich
Glycerol, FCC, FG
Sigma-Aldrich
Glycerol, ≥99.5%
Sigma-Aldrich
Glycerol, for molecular biology, ≥99.0%
Sigma-Aldrich
Glycerol, BioUltra, for molecular biology, anhydrous, ≥99.5% (GC)