- Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes.
Pd-catalyzed β-selective direct C-H bond arylation of thiophenes with aryltrimethylsilanes.
Organic letters (2012-12-12)
Kenji Funaki, Tetsuo Sato, Shuichi Oi
PMID23214502
ABSTRACT
Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl(2)(MeCN)(2) in the presence of CuCl(2) as an oxidant. The reaction preferentially occurred at the β-position of both thiophenes and benzothiophenes.
MATERIALS