Skip to Content
Merck
  • One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Molecules (Basel, Switzerland) (2012-11-13)
Zhang-Gao Le, Zong-Bo Xie, Jian-Ping Xu
ABSTRACT

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions in the presence of Na(2)CO(3), gave the corresponding 2-phenylimidazo[1,2-α]pyridines in excellent yields ranging from 72% to 89%.

MATERIALS
Product Number
Brand
Product Description

Supelco
Sodium carbonate, reference material for titrimetry, certified by BAM, >99.5%
Supelco
Acetophenone, analytical standard
Sigma-Aldrich
Acetophenone, ≥98%, FG
Sigma-Aldrich
Sodium carbonate, ACS reagent, anhydrous, ≥99.5%, powder or granules
Sigma-Aldrich
Sodium carbonate, ACS reagent (primary standard), anhydrous, 99.95-100.05% dry basis
Supelco
Sodium carbonate concentrate, 0.1 M Na2CO3 in water, eluent concentrate for IC
Sigma-Aldrich
Sodium carbonate-12C, 99.9 atom % 12C