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  • Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

Chemical communications (Cambridge, England) (2011-08-11)
Matthew A DeSieno, Wilfred A van der Donk, Huimin Zhao
PMID21829824
ABSTRACT

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.