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  • Bridgehead enolates and bridgehead alkenes in a welwistatin model series.

Bridgehead enolates and bridgehead alkenes in a welwistatin model series.

Chemical communications (Cambridge, England) (2009-03-05)
Valerie Boissel, Nigel S Simpkins, Gurdip Bhalay, Alexander J Blake, William Lewis
ABSTRACT

Bridgehead metallation is possible in a ketone having the welwistatin skeleton, and this facilitates installation of the isothiocyanate function present in the natural product, and also enables synthesis of remarkable bridgehead alkenes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Selenium dioxide, reagent grade, powder, 98%