Skip to Content
Merck
  • Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus.

Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy (2009-02-19)
Hirofumi Shibata, Tatsuro Nakano, M Anowar Khasru Parvez, Yoshihiro Furukawa, Akio Tomoishi, Shingo Niimi, Naokatu Arakaki, Tomihiko Higuti
PMID19223633
ABSTRACT

Using liposome systems, we found that gallates with short alkyl chains were located in the external medium and those with longer alkyl chains were located in the surface region of lipid bilayer. Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (< or = 2 microg/ml).