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  • Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Nucleic acids symposium series (2004) (2007-11-22)
Masahiro Ikejiri, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama
PMID18029775
ABSTRACT

A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.