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Merck

Synthesis of alpha-oximinoketones under ultrasound irradiation.

Ultrasonics sonochemistry (2007-10-26)
Hossein Mehrabi
ABSTRACT

The reaction of 6-acylmethylphenanthridines with isoamyl nitrite results alpha-oximino-6-acylmethylphenanthridines in 73-95% yields in DMF under ultrasound irradiation. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.