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  • [Determination of acid-base amphoteric dissociation constant of 2-methyl-5 (4)-nitroimidazole by UV-spectrophotometry].

[Determination of acid-base amphoteric dissociation constant of 2-methyl-5 (4)-nitroimidazole by UV-spectrophotometry].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (2002-09-06)
S Yang
PMID12212306
ABSTRACT

The 2-methyl-5(4)-nitromidazole(BH) is an ampholyte with acid and base. It is an intermediate of metronidazole. The amphoteric dissociation constant of BH determined by equimolar UV-spectrophotometry. The acidic dissociation constant pKa is 9.64 +/- 0.04 and the basic dissociation constant pKb is 12.98 +/- 0.02.