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Merck

Chemoenzymatic deacylation of ramoplanin.

Bioorganic & medicinal chemistry letters (2012-07-17)
Raffaella Gandolfi, Flavia Marinelli, Enzio Ragg, Diego Romano, Francesco Molinari
PMID22795330
ABSTRACT

The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation.