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  • The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes.

The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes.

Journal of biomedicine & biotechnology (2012-11-03)
Joanne S J Chia, Jennifer L McRae, Peter J Cowan, Karen M Dwyer
PMID23118504
ABSTRACT

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.