- Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
Bioorganic & medicinal chemistry (2007-09-26)
Javier A Ramírez, Andrea C Bruttomesso, Flavia M Michelini, Sofía L Acebedo, Laura E Alché, Lydia R Galagovsky
PMID17892941
ABSTRACT
In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.
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