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SML3244

Sigma-Aldrich

CU-CPD107

≥98% (HPLC)

Synonym(s):

2-(Ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl-1H-imidazole-1-ethanol

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About This Item

Empirical Formula (Hill Notation):
C16H21IN2O2
CAS Number:
2573912-32-8
Molecular Weight:
400.25
UNSPSC Code:
51111800
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)(O)CN(C(COCC)=N1)C(C2=CC=CC=C2)=C1I

InChI

1S/C16H21IN2O2/c1-4-21-10-13-18-15(17)14(12-8-6-5-7-9-12)19(13)11-16(2,3)20/h5-9,20H,4,10-11H2,1-3H3

InChI key

XCYMSVIYUJTAPJ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

CU-CPD107 is a selective and potent inhibitor of Resiquimod-induced Toll-like receptor 8 (TLR8) signaling. Additionally, CU-CPD107 acts as TLR8 agonist in the presence of ssRNA. CU-CPD107 alone is unable to modulate TLR8 signaling.
Selective and potent inhibitor of Resiquimod-induced Toll-like receptor 8 (TLR8); TLR8 agonist in the presence of ssRNA

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000173220
0000181938
0000181939

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Yi Yang et al.
Nature communications, 12(1), 4351-4351 (2021-07-18)
Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an uncontrolled, global inflammatory response.

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