217460

Cardiogenol C

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC₅₀ = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM.

• Synonym(s): Cardiogenol C, 2-(4-Methoxyanilino)-4-(1-hydroxyethylamino)pyrimidine
• Empirical Formula (Hill Notation): C₁₃H₁₆N₄O₂
• CAS Number: 671225-39-1
• Molecular Weight: 260.29
• MDL number: MFCD06798334
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H
• InChI key: QQAHYSZVJLHCNA-UHFFFAOYSA-N

Description

General description

A cell-permeable pyrimidine compound that potently induces the differentiation of ESCs (embryonic stem cells) into cardiomyocytes (EC₅₀ = 100 nM) without significant cytotoxic effect even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is much more efficient than that achieved by EBs (embryoid bodies) formation and DMSO treatment.

A cell-permeable pyrimidine compound that potently induces the differentiation of embryonic stem cells (ESCs) into cardiomyocytes (EC₅₀ = 100 nM). Does not exhibit cytotoxic effects even at concentrations as high as 25 µM. The induction of cardiomyogenesis by Cardiogenol C is reported to be more efficient than that achieved by embryoid bodies (EBs) and DMSO treatment.

Biochem/physiol Actions

Cell permeable: yes

EC50 = 100 nM inducing the differentiation of ESCs (embryonic stem cells) into cardiomyocytes

Primary Target
Differentiation of ESCs (embryonic stem cells) into cardiomyocytes

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wu, X., et al. 2004. J. Am. Chem. Soc.126, 1590.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable