XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Synonyms:
KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Species:
Human XRCC5 (7520), Mouse Xrcc5 (22596), Rat Xrcc5 (363247), Horse XRCC5 (100055031), dog XRCC5 (478902), chicken XRCC5 (424222), Zebrafish xrcc5 (449848), domestic guinea pig Xrcc5 (100728001), naked mole-rat Xrcc5 (101719341), sheep XRCC5 (101107255) ...More
UniProtKB ID:
Gene ID:
- Human(7520) Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
- Mouse(22596) X-ray repair complementing defective repair in Chinese hamster cells 5
- Rat(363247) X-ray repair complementing defective repair in Chinese hamster cells 5
- Horse(100055031) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- dog(478902) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- chicken(424222) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- Zebrafish(449848) X-ray repair complementing defective repair in Chinese hamster cells 5
- domestic guinea pig(100728001) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- naked mole-rat(101719341) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- sheep(101107255) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- Domestic Rabbit(100347656) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- domestic cat(101083534) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
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