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Merck

UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

Synonyms:
SLC25A9
Species:
Human UCP3 (7352), Mouse Ucp3 (22229), Rat Ucp3 (25708), cow UCP3 (281563), sheep UCP3 (443278), Zebrafish ucp3 (794081), chicken UCP3 (373896), dog UCP3 (403575), domestic cat UCP3 (101095610), domestic guinea pig Ucp3 (100726996)
UniProtKB ID:
P55916, O60475, Q96HL3
Gene ID:
  • Human(7352) Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
  • Mouse(22229) uncoupling protein 3 (mitochondrial, proton carrier)
  • Rat(25708) uncoupling protein 3 (mitochondrial, proton carrier)
  • cow(281563) uncoupling protein 3 (mitochondrial, proton carrier)
  • sheep(443278) uncoupling protein 3 (mitochondrial, proton carrier)
  • Zebrafish(794081) uncoupling protein 3
  • chicken(373896) uncoupling protein 3 (mitochondrial, proton carrier)
  • dog(403575) uncoupling protein 3 (mitochondrial, proton carrier)
  • domestic cat(101095610) uncoupling protein 3 (mitochondrial, proton carrier)
  • domestic guinea pig(100726996) uncoupling protein 3 (mitochondrial, proton carrier)
  • naked mole-rat(101713308) uncoupling protein 3 (mitochondrial, proton carrier)

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Antibodies

Product Number
Description
Species Reactivity
Application
AB3046
Anti-Uncoupling Protein 3 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry
western blot