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Merck

TRIM5

tripartite motif containing 5

Synonyms:
RNF88, TRIM5alpha
Species:
Human TRIM5 (85363), Mouse Trim5 (667823), Rat Trim5 (308906), domestic cat TRIM5 (100302544), cow TRIM5 (505265), Domestic Rabbit TRIM5 (100126072)
UniProtKB ID:
Q9C035, A6NGQ1, A8WFA8, D3DQS8, D3DQS9, G3GJY1, Q2MLV4, Q2MLV8
Gene ID:
  • Human(85363) Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
  • Mouse(667823) tripartite motif-containing 5
  • Rat(308906) tripartite motif-containing 5
  • domestic cat(100302544) tripartite motif containing 5
  • cow(505265) tripartite motif containing 5
  • Domestic Rabbit(100126072) tripartite motif containing 5

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