TRIB2
tribbles homolog 2 (Drosophila)
Synonyms:
C5FW, GS3955, TRB2
Species:
Human TRIB2 (28951), Mouse Trib2 (217410), Rat Trib2 (313974), domestic cat TRIB2 (101085367), sheep TRIB2 (101121332), Domestic Rabbit TRIB2 (100357208), domestic guinea pig Trib2 (100718073), naked mole-rat Trib2 (101720665), Zebrafish trib2 (100331041), chicken TRIB2 (378919) ...More
UniProtKB ID:
Gene ID:
- Human(28951) Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
- Mouse(217410) tribbles homolog 2 (Drosophila)
- Rat(313974) tribbles homolog 2 (Drosophila)
- domestic cat(101085367) tribbles homolog 2 (Drosophila)
- sheep(101121332) tribbles homolog 2 (Drosophila)
- Domestic Rabbit(100357208) tribbles homolog 2 (Drosophila)
- domestic guinea pig(100718073) tribbles homolog 2 (Drosophila)
- naked mole-rat(101720665) tribbles homolog 2 (Drosophila)
- Zebrafish(100331041) tribbles homolog 2 (Drosophila)
- chicken(378919) tribbles homolog 2 (Drosophila)
- dog(403884) tribbles homolog 2 (Drosophila)
- cow(352960) tribbles homolog 2 (Drosophila)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.