TK2
thymidine kinase 2, mitochondrial
Synonyms:
MTDPS2, MTTK
Species:
Human TK2 (7084), Mouse Tk2 (57813), Rat Tk2 (291824), chicken TK2 (427551), Zebrafish tk2 (437016), naked mole-rat Tk2 (101704299), domestic guinea pig Tk2 (100727406), sheep TK2 (101103665), cow TK2 (615457), Horse TK2 (100065312) ...More
UniProtKB ID:
Gene ID:
- Human(7084) Summary: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
- Mouse(57813) thymidine kinase 2, mitochondrial
- Rat(291824) thymidine kinase 2, mitochondrial
- chicken(427551) thymidine kinase 2, mitochondrial
- Zebrafish(437016) thymidine kinase 2, mitochondrial
- naked mole-rat(101704299) thymidine kinase 2, mitochondrial
- domestic guinea pig(100727406) thymidine kinase 2, mitochondrial
- sheep(101103665) thymidine kinase 2, mitochondrial
- cow(615457) thymidine kinase 2, mitochondrial
- Horse(100065312) thymidine kinase 2, mitochondrial
- domestic cat(101085008) thymidine kinase 2, mitochondrial
- dog(611387) thymidine kinase 2, mitochondrial
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