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Merck

TAPBP

TAP binding protein (tapasin)

Synonyms:
NGS17, TAPA, TPN, TPSN
Species:
Human TAPBP (6892), Mouse Tapbp (21356), Rat Tapbp (25217), dog TAPBP (481740), naked mole-rat Tapbp (101719224), chicken TAPBP (417048), Zebrafish tapbp (30163), domestic cat TAPBP (101091023), sheep TAPBP (100170652), domestic guinea pig Tapbp (100735947) ...More
UniProtKB ID:
O15533, A2AB91, A2ABC0, B0V003, B0V0A6, B2ZUA4, E9PGM2, O15210
Gene ID:
  • Human(6892) Summary: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(21356) TAP binding protein
  • Rat(25217) TAP binding protein (tapasin)
  • dog(481740) TAP binding protein (tapasin)
  • naked mole-rat(101719224) TAP binding protein (tapasin)
  • chicken(417048) TAP binding protein (tapasin)
  • Zebrafish(30163) TAP binding protein
  • domestic cat(101091023) TAP binding protein (tapasin)
  • sheep(100170652) TAP binding protein (tapasin)
  • domestic guinea pig(100735947) TAP binding protein (tapasin)
  • Horse(100061515) TAP binding protein (tapasin)
  • cow(504335) TAP binding protein (tapasin)

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