TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms:
CHTD2, MAP3K7IP2
Species:
Human TAB2 (23118), Mouse Tab2 (68652), Rat Tab2 (308267), dog TAB2 (484028), chicken TAB2 (421622), Zebrafish tab2 (494163), fruit fly Tab2 (37216), naked mole-rat Tab2 (101698406), domestic guinea pig Tab2 (100717911), sheep TAB2 (101122114) ...More
UniProtKB ID:
Gene ID:
- Human(23118) Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 2008]
- Mouse(68652) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- Rat(308267) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- dog(484028) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- chicken(421622) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- Zebrafish(494163) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- fruit fly(37216) TAK1-associated binding protein 2
- naked mole-rat(101698406) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- domestic guinea pig(100717911) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- sheep(101122114) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- cow(540203) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- Horse(100060433) TGF-beta activated kinase 1/MAP3K7 binding protein 2
- domestic cat(101098714) TGF-beta activated kinase 1/MAP3K7 binding protein 2
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