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Merck

SRC

v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Synonyms:
ASV, SRC1, c-SRC, p60-Src
Species:
Human SRC (6714), Mouse Src (20779), Rat Src (83805), Zebrafish src (325084), chicken SRC (396442), domestic cat SRC (101100378), dog SRC (485864), sheep SRC (101103084), cow SRC (535742), domestic guinea pig Src (100728509)
UniProtKB ID:
P12931, E1P5V4, Q76P87, Q86VB9, Q9H5A8
Gene ID:
  • Human(6714) Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(20779) Rous sarcoma oncogene
  • Rat(83805) v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • Zebrafish(325084) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
  • chicken(396442) v-src sarcoma viral oncogene
  • domestic cat(101100378) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
  • dog(485864) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
  • sheep(101103084) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
  • cow(535742) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
  • domestic guinea pig(100728509) Rous sarcoma oncogene
  • naked mole-rat(101703827) v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Custom & Knockdown Gene Products

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Small Molecule - Antagonist

Product Number
Description
Species
194131
Oxalic acid, 98%,
Species
human
M1296
Malonic acid, ReagentPlus®, 99%,
Species
human
241172
Oxalic acid, ReagentPlus®, ≥99%,
Species
human
W290017
Phosphoric acid solution, 85 wt. % in H2O, FCC, FG,
Species
human
251275
Citric acid, ACS reagent, ≥99.5%,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
05-677
Anti-phospho-Src (Tyr416) Antibody, clone 9A6, clone 9A6, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
04-889
Anti-Src Antibody, clone N6L, rabbit monoclonal, culture supernatant, clone N6L, from rabbit,
Species Reactivity
human
Application
western blot
05-857
Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal, clone 2N8, Upstate®, from rabbit,
Species Reactivity
mouse, vertebrates
Application
western blot
05-185
Anti-avian Src Antibody, clone EC10, clone EC10, Upstate®, from mouse,
Species Reactivity
avian
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
05-184
Anti-Src Antibody, clone GD11, clone GD11, Upstate®, from mouse,
Species Reactivity
avian, human, mink, mouse, rat
Application
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
E2250
Ellagic acid, ≥95% (HPLC), powder, from tree bark,
Species
human, rat

Kits

Product Number
Description
Species
20-121
Src Kinase Reaction Buffer, ,
Species
human

Proteins

Product Number
Description
Species
14-326-M
Src Protein, active, 10 µg, Active, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.,
Species
human
20-110
Src Manganese/ATP Cocktail, ,
Species
human
14-746-M
Src (1-530) Protein, active, 10 µg, ,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
12-140
Src Substrate Peptide, Src Substrate Peptide primarily used in Kinase Assays.,
Species
human