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Merck

SPTLC2

serine palmitoyltransferase, long chain base subunit 2

Synonyms:
HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a
Species:
Human SPTLC2 (9517), Mouse Sptlc2 (20773), Rat Sptlc2 (366697), naked mole-rat Sptlc2 (101702355), sheep SPTLC2 (101115373), Domestic Rabbit SPTLC2 (100358555), cow SPTLC2 (537972), domestic guinea pig Sptlc2 (100719612), Horse SPTLC2 (100059392), domestic cat SPTLC2 (101081055) ...More
UniProtKB ID:
O15270, Q16685
Gene ID:
  • Human(9517) Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
  • Mouse(20773) serine palmitoyltransferase, long chain base subunit 2
  • Rat(366697) serine palmitoyltransferase, long chain base subunit 2
  • naked mole-rat(101702355) serine palmitoyltransferase, long chain base subunit 2
  • sheep(101115373) serine palmitoyltransferase, long chain base subunit 2
  • Domestic Rabbit(100358555) serine palmitoyltransferase, long chain base subunit 2
  • cow(537972) serine palmitoyltransferase, long chain base subunit 2
  • domestic guinea pig(100719612) serine palmitoyltransferase, long chain base subunit 2
  • Horse(100059392) serine palmitoyltransferase, long chain base subunit 2
  • domestic cat(101081055) serine palmitoyltransferase, long chain base subunit 2
  • chicken(423379) serine palmitoyltransferase, long chain base subunit 2
  • dog(480403) serine palmitoyltransferase, long chain base subunit 2

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