SPHK2
sphingosine kinase 2
Synonyms:
SK 2, SK-2, SPK 2, SPK-2
Species:
Human SPHK2 (56848), Mouse Sphk2 (56632), Rat Sphk2 (308589), sheep SPHK2 (101106964), cow SPHK2 (533103), Horse SPHK2 (100054066), domestic cat SPHK2 (101081345), dog SPHK2 (484401), Zebrafish sphk2 (100150090), naked mole-rat Sphk2 (101720879)
UniProtKB ID:
Gene ID:
- Human(56848) Summary: This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
- Mouse(56632) sphingosine kinase 2
- Rat(308589) sphingosine kinase 2
- sheep(101106964) sphingosine kinase 2
- cow(533103) sphingosine kinase 2
- Horse(100054066) sphingosine kinase 2
- domestic cat(101081345) sphingosine kinase 2
- dog(484401) sphingosine kinase 2
- Zebrafish(100150090) sphingosine kinase 2
- naked mole-rat(101720879) sphingosine kinase 2
- domestic guinea pig(100730608) sphingosine kinase 2
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