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Merck

SLC7A11

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Synonyms:
CCBR1, xCT
Species:
Human SLC7A11 (23657), Mouse Slc7a11 (26570), Rat Slc7a11 (310392), naked mole-rat Slc7a11 (101709765), domestic guinea pig Slc7a11 (100735308), domestic cat SLC7A11 (101099374), dog SLC7A11 (483821), chicken SLC7A11 (428731), sheep SLC7A11 (100820755), cow SLC7A11 (524078)
UniProtKB ID:
Q9UPY5, A8K2U4
Gene ID:
  • Human(23657) Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
  • Mouse(26570) solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
  • Rat(310392) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • naked mole-rat(101709765) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • domestic guinea pig(100735308) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • domestic cat(101099374) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • dog(483821) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • chicken(428731) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • sheep(100820755) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
  • cow(524078) solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

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