SIRT6
sirtuin 6
Synonyms:
SIR2L6
Species:
Human SIRT6 (51548), Mouse Sirt6 (50721), Rat Sirt6 (299638), naked mole-rat Sirt6 (101706114), sheep SIRT6 (101113327), chicken SIRT6 (428332), domestic cat SIRT6 (101100540), cow SIRT6 (535416), Zebrafish sirt6 (415161), dog SIRT6 (485045) ...More
UniProtKB ID:
Gene ID:
- Human(51548) Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
- Mouse(50721) sirtuin 6
- Rat(299638) sirtuin 6
- naked mole-rat(101706114) sirtuin 6
- sheep(101113327) sirtuin 6
- chicken(428332) sirtuin 6
- domestic cat(101100540) sirtuin 6
- cow(535416) sirtuin 6
- Zebrafish(415161) sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
- dog(485045) sirtuin 6
- fruit fly(41254) CG6284 gene product from transcript CG6284-RB
- domestic guinea pig(100734667) sirtuin 6
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