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Merck

SERPINA7

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

Synonyms:
TBG
Species:
Human SERPINA7 (6906), Mouse Serpina7 (331535), Rat Serpina7 (81806), naked mole-rat Serpina7 (101700129), domestic guinea pig Serpina7 (100730068), sheep SERPINA7 (443462), Zebrafish serpina7 (449799), domestic cat SERPINA7 (101100545), cow SERPINA7 (282518), dog SERPINA7 (481007)
UniProtKB ID:
P05543, D3DUX1
Gene ID:
  • Human(6906) Summary: There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
  • Mouse(331535) serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • Rat(81806) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • naked mole-rat(101700129) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • domestic guinea pig(100730068) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • sheep(443462) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • Zebrafish(449799) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • domestic cat(101100545) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • cow(282518) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
  • dog(481007) serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

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