RB1
retinoblastoma 1
Synonyms:
OSRC, RB, p105-Rb, pRb, pp110
Species:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), chicken RB1 (386582), Zebrafish rb1 (777733), domestic cat RB1 (101101356), dog RB1 (476915), cow RB1 (534712), Horse RB1 (100057080), sheep RB1 (100144755) ...More
UniProtKB ID:
Gene ID:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- dog(476915) retinoblastoma 1
- cow(534712) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
Custom & Knockdown Gene Products
siRNA
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Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Kits
Product Number
Description
Species
CpG WIZ™ RB1 - Methylation specific PCR assay, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Species
human
Proteins
Product Number
Description
Species
Retinoblastoma Protein (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Species
human