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Merck

RAP1GAP

RAP1 GTPase activating protein

Synonyms:
RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
Species:
Human RAP1GAP (5909), Mouse Rap1gap (110351), Rat Rap1gap (313644), Domestic Rabbit RAP1GAP (100340849), domestic cat RAP1GAP (101093787), chicken RAP1GAP (769475), naked mole-rat Rap1gap (101726267), Zebrafish rap1gap (100538309), sheep RAP1GAP (101104377), Zebrafish rap1gap (100144557) ...More
UniProtKB ID:
P47736, J3QSS6, O75062, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
Gene ID:
  • Human(5909) Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
  • Mouse(110351) Rap1 GTPase-activating protein
  • Rat(313644) Rap1 GTPase-activating protein
  • Domestic Rabbit(100340849) RAP1 GTPase activating protein
  • domestic cat(101093787) RAP1 GTPase activating protein
  • chicken(769475) RAP1 GTPase activating protein
  • naked mole-rat(101726267) RAP1 GTPase activating protein
  • Zebrafish(100538309) RAP1 GTPase activating protein
  • sheep(101104377) RAP1 GTPase activating protein
  • Zebrafish(100144557) RAP1 GTPase activating protein
  • domestic guinea pig(100725658) RAP1 GTPase activating protein
  • dog(487387) RAP1 GTPase activating protein
  • cow(532839) RAP1 GTPase activating protein

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