PTAFR
platelet-activating factor receptor
Synonyms:
PAFR
Species:
Human PTAFR (5724), Mouse Ptafr (19204), Rat Ptafr (58949), domestic guinea pig Ptafr (100720710), sheep PTAFR (443041), sheep PTAFR (101104560), Goat PTAFR (100860976), cow PTAFR (518283), domestic cat PTAFR (101085906), naked mole-rat Ptafr (101711912) ...More
UniProtKB ID:
Gene ID:
- Human(5724) Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- Mouse(19204) platelet-activating factor receptor
- Rat(58949) platelet-activating factor receptor
- domestic guinea pig(100720710) platelet-activating factor receptor
- sheep(443041) platelet-activating factor receptor
- sheep(101104560) platelet-activating factor receptor
- Goat(100860976) platelet-activating factor receptor
- cow(518283) platelet-activating factor receptor
- domestic cat(101085906) platelet-activating factor receptor
- naked mole-rat(101711912) platelet-activating factor receptor
- chicken(428209) platelet-activating factor receptor
- dog(487336) platelet-activating factor receptor
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.