PRKCZ
protein kinase C, zeta
Synonyms:
PKC-ZETA, PKC2
Species:
Human PRKCZ (5590), Mouse Prkcz (18762), Rat Prkcz (25522), dog PRKCZ (479577), chicken PRKCZ (419399), domestic cat PRKCZ (101087851), Domestic Rabbit PRKCZ (100009538), sheep PRKCZ (101122295), naked mole-rat Prkcz (101699303), domestic guinea pig Prkcz (100734946) ...More
UniProtKB ID:
Gene ID:
- Human(5590) Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(18762) protein kinase C, zeta
- Rat(25522) protein kinase C, zeta
- dog(479577) protein kinase C, zeta
- chicken(419399) protein kinase C, zeta
- domestic cat(101087851) protein kinase C, zeta
- Domestic Rabbit(100009538) protein kinase C, zeta
- sheep(101122295) protein kinase C, zeta
- naked mole-rat(101699303) protein kinase C, zeta
- domestic guinea pig(100734946) protein kinase C, zeta
- cow(286877) protein kinase C, zeta
- Zebrafish(555737) protein kinase C, zeta
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