PLAGL1
pleiomorphic adenoma gene-like 1
Synonyms:
LOT1, ZAC, ZAC1
Species:
Human PLAGL1 (5325), Mouse Plagl1 (22634), Rat Plagl1 (25157), sheep PLAGL1 (101119399), cow PLAGL1 (539761), domestic guinea pig Plagl1 (100735816), naked mole-rat Plagl1 (101718544), chicken PLAGL1 (421664), dog PLAGL1 (484018), domestic cat PLAGL1 (101092436)
UniProtKB ID:
Gene ID:
- Human(5325) Summary: This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
- Mouse(22634) pleiomorphic adenoma gene-like 1
- Rat(25157) pleiomorphic adenoma gene-like 1
- sheep(101119399) pleiomorphic adenoma gene-like 1
- cow(539761) pleiomorphic adenoma gene-like 1
- domestic guinea pig(100735816) pleiomorphic adenoma gene-like 1
- naked mole-rat(101718544) pleiomorphic adenoma gene-like 1
- chicken(421664) pleiomorphic adenoma gene-like 1
- dog(484018) pleiomorphic adenoma gene-like 1
- domestic cat(101092436) pleiomorphic adenoma gene-like 1
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