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Merck

PDK3

pyruvate dehydrogenase kinase, isozyme 3

Synonyms:
Species:
Human PDK3 (5165), Mouse Pdk3 (236900), Rat Pdk3 (296849), Horse PDK3 (100060791), domestic cat PDK3 (101095314), dog PDK3 (480868), domestic guinea pig Pdk3 (100725367), chicken PDK3 (418595), sheep PDK3 (101108725), naked mole-rat Pdk3 (101699582)
UniProtKB ID:
Q15120, B4DXG6
Gene ID:
  • Human(5165) Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
  • Mouse(236900) pyruvate dehydrogenase kinase, isoenzyme 3
  • Rat(296849) pyruvate dehydrogenase kinase, isozyme 3
  • Horse(100060791) pyruvate dehydrogenase kinase, isozyme 3
  • domestic cat(101095314) pyruvate dehydrogenase kinase, isozyme 3
  • dog(480868) pyruvate dehydrogenase kinase, isozyme 3
  • domestic guinea pig(100725367) pyruvate dehydrogenase kinase, isozyme 3
  • chicken(418595) pyruvate dehydrogenase kinase, isozyme 3
  • sheep(101108725) pyruvate dehydrogenase kinase, isozyme 3
  • naked mole-rat(101699582) pyruvate dehydrogenase kinase, isozyme 3
  • cow(510841) pyruvate dehydrogenase kinase, isozyme 3

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