PDE3A
phosphodiesterase 3A, cGMP-inhibited
Synonyms:
CGI-PDE, CGI-PDE A, CGI-PDE-A
Species:
Human PDE3A (5139), Mouse Pde3a (54611), Rat Pde3a (50678), domestic cat PDE3A (101088586), naked mole-rat Pde3a (101704787), Domestic Rabbit PDE3A (100009330), Horse PDE3A (100034086), sheep PDE3A (101115870), Zebrafish pde3a (567051), cow PDE3A (536636) ...More
UniProtKB ID:
Gene ID:
- Human(5139) Summary: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
- Mouse(54611) phosphodiesterase 3A, cGMP inhibited
- Rat(50678) phosphodiesterase 3A, cGMP inhibited
- domestic cat(101088586) phosphodiesterase 3A, cGMP-inhibited
- naked mole-rat(101704787) phosphodiesterase 3A, cGMP-inhibited
- Domestic Rabbit(100009330) phosphodiesterase 3A, cGMP-inhibited
- Horse(100034086) phosphodiesterase 3A, cGMP-inhibited
- sheep(101115870) phosphodiesterase 3A, cGMP-inhibited
- Zebrafish(567051) phosphodiesterase 3A, cGMP-inhibited
- cow(536636) phosphodiesterase 3A, cGMP-inhibited
- chicken(418185) phosphodiesterase 3A, cGMP-inhibited
- domestic guinea pig(100302667) phosphodiesterase 3A, cGMP inhibited
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Small Molecule - Inhibitor
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