PCSK1
proprotein convertase subtilisin/kexin type 1
Synonyms:
BMIQ12, NEC1, PC1, PC3, SPC3
Species:
Human PCSK1 (5122), Mouse Pcsk1 (18548), Rat Pcsk1 (25204), domestic guinea pig Pcsk1 (100732445), naked mole-rat Pcsk1 (101704290), cow PCSK1 (281967), domestic cat PCSK1 (101082627), Zebrafish pcsk1 (100005716), chicken PCSK1 (769230), Horse PCSK1 (100064886)
UniProtKB ID:
Gene ID:
- Human(5122) Summary: The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
- Mouse(18548) proprotein convertase subtilisin/kexin type 1
- Rat(25204) proprotein convertase subtilisin/kexin type 1
- domestic guinea pig(100732445) proprotein convertase subtilisin/kexin type 1
- naked mole-rat(101704290) proprotein convertase subtilisin/kexin type 1
- cow(281967) proprotein convertase subtilisin/kexin type 1
- domestic cat(101082627) proprotein convertase subtilisin/kexin type 1
- Zebrafish(100005716) proprotein convertase subtilisin/kexin type 1
- chicken(769230) proprotein convertase subtilisin/kexin type 1
- Horse(100064886) proprotein convertase subtilisin/kexin type 1
- dog(479149) proprotein convertase subtilisin/kexin type 1
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