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Merck

PARK2

parkinson protein 2, E3 ubiquitin protein ligase (parkin)

Synonyms:
AR-JP, LPRS2, PDJ, PRKN
Species:
Human PARK2 (5071), Mouse Park2 (50873), Rat Park2 (56816), cow PARK2 (530858), naked mole-rat Park2 (101700770), domestic guinea pig Park2 (100724550), Horse PARK2 (100057832), Zebrafish park2 (550328), chicken PARK2 (421577), dog PARK2 (612316) ...More
UniProtKB ID:
O60260, A3FG77, A8K975, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44
Gene ID:
  • Human(5071) Summary: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
  • Mouse(50873) Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • Rat(56816) parkinson protein 2, E3 ubiquitin protein ligase
  • cow(530858) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • naked mole-rat(101700770) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • domestic guinea pig(100724550) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Horse(100057832) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • Zebrafish(550328) Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • chicken(421577) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • dog(612316) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • domestic cat(101098228) parkinson protein 2, E3 ubiquitin protein ligase (parkin)
  • sheep(101113503) parkinson protein 2, E3 ubiquitin protein ligase (parkin)

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Antibodies

Product Number
Description
Species Reactivity
Application
05-882
Anti-Parkin Antibody, clone PRK8, ascites fluid, clone PRK8, Upstate®,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
AB5112
Anti-Parkin Antibody, a.a. 305-323, serum, Chemicon®,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry
western blot