NQO1
NAD(P)H dehydrogenase, quinone 1
Synonyms:
DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Species:
Human NQO1 (1728), Mouse Nqo1 (18104), Rat Nqo1 (24314), chicken NQO1 (769737), domestic guinea pig Nqo1 (100135582), domestic cat NQO1 (101097859), Zebrafish nqo1 (322506), cow NQO1 (519632), sheep NQO1 (101121876), naked mole-rat Nqo1 (101711262)
UniProtKB ID:
Gene ID:
- Human(1728) Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(18104) NAD(P)H dehydrogenase, quinone 1
- Rat(24314) NAD(P)H dehydrogenase, quinone 1
- chicken(769737) NAD(P)H dehydrogenase, quinone 1
- domestic guinea pig(100135582) NAD(P)H dehydrogenase, quinone 1
- domestic cat(101097859) NAD(P)H dehydrogenase, quinone 1
- Zebrafish(322506) NAD(P)H dehydrogenase, quinone 1
- cow(519632) NAD(P)H dehydrogenase, quinone 1
- sheep(101121876) NAD(P)H dehydrogenase, quinone 1
- naked mole-rat(101711262) NAD(P)H dehydrogenase, quinone 1
- dog(610935) NAD(P)H dehydrogenase, quinone 1
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