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Merck

NLRP2

NLR family, pyrin domain containing 2

Synonyms:
CLR19.9, NALP2, NBS1, PAN1, PYPAF2
Species:
Human NLRP2 (55655), Mouse Nlrp2 (232827), cow NLRP2 (100301026), dog NLRP2 (484304), sheep NLRP2 (101123321), Domestic Rabbit NLRP2 (100344125), domestic cat NLRP2 (101093815), Horse NLRP2 (100055187)
UniProtKB ID:
Q9NX02, B4DZL7, I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6
Gene ID:
  • Human(55655) Summary: NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]
  • Mouse(232827) NLR family, pyrin domain containing 2
  • cow(100301026) NLR family, pyrin domain containing 2
  • dog(484304) NLR family, pyrin domain containing 2
  • sheep(101123321) NLR family, pyrin domain containing 2
  • Domestic Rabbit(100344125) NLR family, pyrin domain containing 2
  • domestic cat(101093815) NLR family, pyrin domain containing 2
  • Horse(100055187) NLR family, pyrin domain containing 2

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