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Merck

NFYA

nuclear transcription factor Y, alpha

Synonyms:
CBF-A, CBF-B, HAP2, NF-YA
Species:
Human NFYA (4800), Mouse Nfya (18044), Rat Nfya (29508), domestic cat NFYA (101098871), naked mole-rat Nfya (101717746), cow NFYA (539584), dog NFYA (474897), Horse NFYA (100054237), chicken NFYA (419917), Zebrafish nfya (83915) ...More
UniProtKB ID:
P23511, Q8IXU0
Gene ID:
  • Human(4800) Summary: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(18044) nuclear transcription factor-Y alpha
  • Rat(29508) nuclear transcription factor-Y alpha
  • domestic cat(101098871) nuclear transcription factor Y, alpha
  • naked mole-rat(101717746) nuclear transcription factor Y, alpha
  • cow(539584) nuclear transcription factor Y, alpha
  • dog(474897) nuclear transcription factor Y, alpha
  • Horse(100054237) nuclear transcription factor Y, alpha
  • chicken(419917) nuclear transcription factor Y, alpha
  • Zebrafish(83915) nuclear transcription factor Y, alpha
  • domestic guinea pig(100717576) nuclear transcription factor Y, alpha
  • sheep(101104434) nuclear transcription factor Y, alpha

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