MCM4
minichromosome maintenance complex component 4
Synonyms:
CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21
Species:
Human MCM4 (4173), Mouse Mcm4 (17217), Rat Mcm4 (29728), Thale Cress MCM4 (816142), Zebrafish mcm4 (337598), domestic guinea pig Mcm4 (100724549), naked mole-rat Mcm4 (101721409), domestic cat MCM4 (101089576), sheep MCM4 (101105420), cow MCM4 (504367) ...More
UniProtKB ID:
Gene ID:
- Human(4173) Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
- Mouse(17217) minichromosome maintenance deficient 4 homolog (S. cerevisiae)
- Rat(29728) minichromosome maintenance complex component 4
- Thale Cress(816142) minichromosome maintenance protein 4
- Zebrafish(337598) MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)
- domestic guinea pig(100724549) minichromosome maintenance complex component 4
- naked mole-rat(101721409) minichromosome maintenance complex component 4
- domestic cat(101089576) minichromosome maintenance complex component 4
- sheep(101105420) minichromosome maintenance complex component 4
- cow(504367) minichromosome maintenance complex component 4
- dog(477871) minichromosome maintenance complex component 4
- Horse(100051303) minichromosome maintenance complex component 4
- chicken(426764) minichromosome maintenance complex component 4
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