MAP2K2
mitogen-activated protein kinase kinase 2
Synonyms:
CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Species:
Human MAP2K2 (5605), Mouse Map2k2 (26396), Rat Map2k2 (58960), chicken MAP2K2 (396349), dog MAP2K2 (611939), cow MAP2K2 (510434), sheep MAP2K2 (101113846), naked mole-rat Map2k2 (101707562), domestic guinea pig Map2k2 (100728923)
UniProtKB ID:
Gene ID:
- Human(5605) Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(26396) mitogen-activated protein kinase kinase 2
- Rat(58960) mitogen activated protein kinase kinase 2
- chicken(396349) mitogen-activated protein kinase kinase 2
- dog(611939) mitogen-activated protein kinase kinase 2
- cow(510434) mitogen-activated protein kinase kinase 2
- sheep(101113846) mitogen-activated protein kinase kinase 2
- naked mole-rat(101707562) mitogen-activated protein kinase kinase 2
- domestic guinea pig(100728923) mitogen-activated protein kinase kinase 2
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