LRP6
low density lipoprotein receptor-related protein 6
Synonyms:
ADCAD2
Species:
Human LRP6 (4040), Mouse Lrp6 (16974), Rat Lrp6 (312781), domestic guinea pig Lrp6 (100735282), naked mole-rat Lrp6 (101703711), domestic cat LRP6 (101082246), Horse LRP6 (100063409), dog LRP6 (477692), sheep LRP6 (101112971), Domestic Rabbit LRP6 (100352000) ...More
UniProtKB ID:
Gene ID:
- Human(4040) Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
- Mouse(16974) low density lipoprotein receptor-related protein 6
- Rat(312781) low density lipoprotein receptor-related protein 6
- domestic guinea pig(100735282) low density lipoprotein receptor-related protein 6
- naked mole-rat(101703711) low density lipoprotein receptor-related protein 6
- domestic cat(101082246) low density lipoprotein receptor-related protein 6
- Horse(100063409) low density lipoprotein receptor-related protein 6
- dog(477692) low density lipoprotein receptor-related protein 6
- sheep(101112971) low density lipoprotein receptor-related protein 6
- Domestic Rabbit(100352000) low density lipoprotein receptor-related protein 6
- Zebrafish(100003877) low-density lipoprotein receptor-related protein 6
- chicken(419097) low density lipoprotein receptor-related protein 6
- cow(536328) low density lipoprotein receptor-related protein 6
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