LRP2
low density lipoprotein receptor-related protein 2
Synonyms:
DBS, GP330
Species:
Human LRP2 (4036), Mouse Lrp2 (14725), Rat Lrp2 (29216), domestic guinea pig Lrp2 (100713603), naked mole-rat Lrp2 (101717800), domestic cat LRP2 (101087337), Horse LRP2 (100062836), cow LRP2 (100337021), dog LRP2 (478781), Domestic Rabbit LRP2 (100346275) ...More
UniProtKB ID:
Gene ID:
- Human(4036) Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
- Mouse(14725) low density lipoprotein receptor-related protein 2
- Rat(29216) low density lipoprotein receptor-related protein 2
- domestic guinea pig(100713603) low density lipoprotein receptor-related protein 2
- naked mole-rat(101717800) low density lipoprotein receptor-related protein 2
- domestic cat(101087337) low density lipoprotein receptor-related protein 2
- Horse(100062836) low density lipoprotein receptor-related protein 2
- cow(100337021) low density lipoprotein receptor-related protein 2
- dog(478781) low density lipoprotein receptor-related protein 2
- Domestic Rabbit(100346275) low density lipoprotein receptor-related protein 2
- sheep(101108200) low density lipoprotein receptor-related protein 2
- chicken(424168) low density lipoprotein receptor-related protein 2
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