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Merck

LIN28B

lin-28 homolog B (C. elegans)

Synonyms:
CSDD2
Species:
Human LIN28B (389421), Mouse Lin28b (380669), Rat Lin28b (689054), chicken LIN28B (421786), sheep LIN28B (100861578), cow LIN28B (540646), domestic cat LIN28B (101090940), dog LIN28B (481943), domestic guinea pig Lin28b (100734141)
UniProtKB ID:
Q6ZN17, A1L165, B2RPN6, Q5TCM4
Gene ID:
  • Human(389421) Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
  • Mouse(380669) lin-28 homolog B (C. elegans)
  • Rat(689054) lin-28 homolog B (C. elegans)
  • chicken(421786) lin-28 homolog B (C. elegans)
  • sheep(100861578) lin-28 homolog B (C. elegans)
  • cow(540646) lin-28 homolog B (C. elegans)
  • domestic cat(101090940) lin-28 homolog B (C. elegans)
  • dog(481943) lin-28 homolog B (C. elegans)
  • domestic guinea pig(100734141) lin-28 homolog B (C. elegans)

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