LGI1
leucine-rich, glioma inactivated 1
Synonyms:
ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099
Species:
Human LGI1 (9211), Mouse Lgi1 (56839), Rat Lgi1 (252892), sheep LGI1 (101105294), dog LGI1 (477777), Domestic Rabbit LGI1 (100344253), naked mole-rat Lgi1 (101703526), domestic cat LGI1 (101088030), domestic guinea pig Lgi1 (100726518), cow LGI1 (617080)
UniProtKB ID:
Gene ID:
- Human(9211) Summary: This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008]
- Mouse(56839) leucine-rich repeat LGI family, member 1
- Rat(252892) leucine-rich, glioma inactivated 1
- sheep(101105294) leucine-rich, glioma inactivated 1
- dog(477777) leucine-rich, glioma inactivated 1
- Domestic Rabbit(100344253) leucine-rich, glioma inactivated 1
- naked mole-rat(101703526) leucine-rich, glioma inactivated 1
- domestic cat(101088030) leucine-rich, glioma inactivated 1
- domestic guinea pig(100726518) leucine-rich, glioma inactivated 1
- cow(617080) leucine-rich, glioma inactivated 1
- chicken(423802) leucine-rich, glioma inactivated 1
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