LDB3
LIM domain binding 3
Synonyms:
CMD1C, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP
Species:
Human LDB3 (11155), Mouse Ldb3 (24131), Rat Ldb3 (498587), chicken LDB3 (423610), Domestic Rabbit LDB3 (100348927), cow LDB3 (536781), dog LDB3 (479269), domestic guinea pig Ldb3 (100724737), sheep LDB3 (101111515)
UniProtKB ID:
Gene ID:
- Human(11155) Summary: This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
- Mouse(24131) LIM domain binding 3
- Rat(498587) LIM domain binding 3
- chicken(423610) LIM domain binding 3
- Domestic Rabbit(100348927) LIM domain binding 3
- cow(536781) LIM domain binding 3
- dog(479269) LIM domain binding 3
- domestic guinea pig(100724737) LIM domain binding 3
- sheep(101111515) LIM domain binding 3
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