KLRK1
killer cell lectin-like receptor subfamily K, member 1
Synonyms:
CD314, D12S2489E, KLR, NKG2-D, NKG2D
Species:
Human KLRK1 (22914), Mouse Klrk1 (27007), Rat Klrk1 (24934), domestic guinea pig Klrk1 (100723644), cow KLRK1 (404058), dog KLRK1 (611355), domestic cat KLRK1 (101086984)
UniProtKB ID:
Gene ID:
- Human(22914) Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
- Mouse(27007) killer cell lectin-like receptor subfamily K, member 1
- Rat(24934) killer cell lectin-like receptor subfamily K, member 1
- domestic guinea pig(100723644) killer cell lectin-like receptor subfamily K, member 1
- cow(404058) killer cell lectin-like receptor subfamily K, member 1
- dog(611355) killer cell lectin-like receptor subfamily K, member 1
- domestic cat(101086984) killer cell lectin-like receptor subfamily K, member 1
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