INHBA
inhibin, beta A
Synonyms:
EDF, FRP
Species:
Human INHBA (3624), Mouse Inhba (16323), Rat Inhba (29200), domestic cat INHBA (493853), chicken INHBA (396361), cow INHBA (281867), naked mole-rat Inhba (101704279), domestic guinea pig Inhba (100720616), sheep INHBA (443524), Goat INHBA (100860960) ...More
UniProtKB ID:
Gene ID:
- Human(3624) Summary: The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
- Mouse(16323) inhibin beta-A
- Rat(29200) inhibin beta-A
- domestic cat(493853) inhibin, beta A
- chicken(396361) inhibin, beta A
- cow(281867) inhibin, beta A
- naked mole-rat(101704279) inhibin, beta A
- domestic guinea pig(100720616) inhibin, beta A
- sheep(443524) inhibin, beta A
- Goat(100860960) inhibin, beta A
- Horse(100034076) inhibin, beta A
- dog(483245) inhibin, beta A
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