ING3
inhibitor of growth family, member 3
Synonyms:
Eaf4, ING2, MEAF4, p47ING3
Species:
Human ING3 (54556), Mouse Ing3 (71777), Rat Ing3 (312154), domestic guinea pig Ing3 (100721269), sheep ING3 (101102722), cow ING3 (513000), dog ING3 (475299), Zebrafish ing3 (393911), naked mole-rat Ing3 (101711218), domestic cat ING3 (101089592) ...More
UniProtKB ID:
Gene ID:
- Human(54556) Summary: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(71777) inhibitor of growth family, member 3
- Rat(312154) inhibitor of growth family, member 3
- domestic guinea pig(100721269) inhibitor of growth family, member 3
- sheep(101102722) inhibitor of growth family, member 3
- cow(513000) inhibitor of growth family, member 3
- dog(475299) inhibitor of growth family, member 3
- Zebrafish(393911) inhibitor of growth family, member 3
- naked mole-rat(101711218) inhibitor of growth family, member 3
- domestic cat(101089592) inhibitor of growth family, member 3
- chicken(417762) inhibitor of growth family, member 3
- Horse(100056220) inhibitor of growth family, member 3
- fruit fly(32853) CG6632 gene product from transcript CG6632-RA
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